LONDON, 10 March 2016 – Synthace scientists have published a feature review in Cell Press: Trends in Biotechnology’s special Industrial Biotechnology March 2016 issue entitled “Harnessing QbD, Programming Languages, and Automation for Reproducible Biology”. The paper is open access www.cell.com/trends/biotechnology/fulltext/S0167-7799(15)00246-2 and can be downloaded here.
Building robust biomanufacturing processes is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and to manage knowledge, data, and materials. For bioengineering to fully access biological potential, it will require application of statistically designed experiments to derive detailed empirical models of underlying systems.
This requires execution of large-scale structured experimentation for which flexible laboratory automation is necessary. This necessitates development of expressive, high-level languages such as Antha that allow reusability of protocols, characterization of their reliability, and a change in focus from implementation details to functional properties. This paper reviews developments in these areas and identifies what we at Synthace believe is an exciting trend that promises to revolutionize biotechnology.
Synthace engineers biology for applications across health, food, energy and manufacturing. Combining computation, biology and automation the company rapidly develops robust, high yielding bioprocesses to make bio-based products with strategic partners. Central to Synthace’s technology is Antha, a platform that brings quality by design and design for manufacturing to biological research and development. Learn more at www.synthace.com and www.antha.com.
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