Automation for Biologics R&D

Our industrially validated software platform for antibody engineering, cell line development and bioprocessing increases throughput, improves quality and reduces cost.

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Challenges

Synthace Solution

 
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A need to accelerate throughput.

Modern screening platforms churn out 100s of potential preclinical candidates which all need to be engineered into expression constructs: moving the bottleneck towards Ab engineering.

High Throughput Automated Workflows

Our platform incorporates robust pre-optimised automated molecular biology methods, these save time and resource when constructing high volumes of tedious experiments such as multi-part construct assemblies.

 
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Higher Quality: Increased Quantity

Cell Line Development and Upstream Process Development teams are under increasing pressure to deliver increased quantities of high-quality/robust pre-clinical candidates.

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Complex Experiments can become routine

Our software makes complex experiments such as Design of Experiments (DoE) routine. It allows you to quickly set-up and run a complex DoE on your existing lab equipment, without needing to call an external engineer.

 
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Data has become a bottleneck

Lab Equipment now spews out more data. Unfortunately, ways of working and the associated tools haven’t kept up with this data revolution.

Seamless Data integration

Seamless structuring and plotting of off-line and on-line data shortens the time to actionable insight and opens up your lab to advanced machine learning methods.

 
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Automated Biologics R&D in Action

High Throughput Type IIS Construct Assembly

In this case study, we demonstrate how we optimised an in-house Type IIS protocol, and how we have subsequently integrated this with other common Molecular Biology protocols.

The Synthace Molecular Biology workflow is designed specifically to work with your existing automation equipment and has been shown to lead to increases in throughput and an increase in walk-away time.

  1. Works at room temperature in 1-pot.

  2. Reduced time with no pre-digestion needed

  3. Increases process robustness with multipart construct assembly

Automated Design of Experiments

In this case study, we demonstrate how we have deployed our Design of Experiments Optimisation workflow to industry to optimise a protein expression.

The Synthace Optimisation workflows is designed specifically to work with your existing automation equipment and has been shown to lead to increases in throughput and an increase in walk-away time. Some examples of where partners are currently using this include:

  1. Protein Expression Media Optimisation

  2. Transfection/Transduction Optimisation

  3. Enzymatic Reaction Optimisation

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