DOE is often applied to systems that have many continuous variables, like in assay development where we look to optimize the concentrations of multiple assay components.
However, genetic code offers a very different challenge. How do we optimize a huge number of categoric variables, each with four potential levels: A, T, G or C?
In this webinar, Dr Claes Gustafsson from Atum and Dr Markus Gershater from Synthace will walk you through:
- How DOE-like approaches can be applied to such a challenging design space
- With examples covering the systematic optimization of:
- Promoters
- Genes
- And Proteins
- How to apply DOE methodology to genetic code.
Recorded July 27, 2022
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Speakers
Markus Gershater
Chief Scientific Officer & Co-Founder - Synthace
Markus Gershater
Chief Scientific Officer & Co-Founder - Synthace
Markus co-founded Synthace after working as a Research Associate in Synthetic Biology at University College London where he developed novel biosynthesis methods using pathway engineering.
Prior to UCL, he was a Biotransformation Scientist at Novacta Biosystems working as part of the industrial biotechnology group that conducted more than 90 contract research projects for over 20 clients. Markus has a PhD in Plant Biochemistry from Durham.
Claes Gustafsson
Chief Commercial Officer & Co-Founder - Atum
Claes Gustafsson
Chief Commercial Officer & Co-Founder - Atum
As ATUM’s Co-Founder and CCO, Dr. Gustafsson oversees most of the company's external communications. Prior to co-founding ATUM, Dr. Gustafsson led, managed and collaborated with key strategic teams at Maxygen Inc.
Before Maxygen, Dr. Gustafsson worked as a scientist at Kosan Biosciences, a number of research, teaching, and post-doctoral positions at UCs Santa Cruz and San Francisco, and at University of Umeå. He received his Ph.D. in Molecular Biology/Biochemistry from the University of Umeå, Sweden.